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Mechanistically, the dynactin subunit p150(Glued) transports IGF-IR to the nuclear pore complex, where importin- and RanBP2 interact with IGF-IR and then deliver it into the nucleus [83]

All the patients fulfilled the criteria established by the American Society for Reproductive Medicine and the European Society for Human Reproduction and Embryology for diagnosing the presence of PCOS (20), and at least two of the following criteria had to be present: (a) oligomenorrhea with inter-menstrual intervals longer than 45 days, (b) clinical (acne, hirsutism) or biochemical signs of hyperandrogenism, (c) the presence of micro-polycystic ovaries at ultrasound

& Kashiwagi, K

doi: 10.1021/acs.chemrev.0c01108 24 SchmidtMFSchlesingerMJ

9013029) with the GPhC

Leirs, G