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Randomization and masking Randomization (1:1) to semaglutide 2.4 mg or placebo was done centrally by the clinical research organization (Parexel) in a double-blind manner using an interactive web-based response system (IWRS) with a fixed-size blocking schema, without stratification

Neuroinflammation or fever is presumed to also trigger ISR, as autoantibodies may target neural or immune systems and cause inflammation elsewhere (418)

Pegsebrenatide was built from the start to act on microglia and astrocytes, the support cells whose chronic activation is now understood to drive a substantial portion of neurodegenerative pathology

Step 8: Hold for 10 seconds

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