Although the hormone showed activity, its short half-life made it impractical for therapeutic use
doi: 10.1046/j.1471-4159.2003.02073.x 47 ChangYFZhangDHuWMLiuDXLiL
A Cochrane review of 15 randomized controlled trials found that folic acid supplements, taken alone or with other B vitamins, compared with a placebo did not show a significant difference on rates of heart attack and cardiovascular disease deaths but it did reduce the risk of stroke

Ingredients: Purified Water, Ethylhexyl Palmitate, Glycereth-26, Glycerin, Cetearyl Alcohol, Niacinamide, Hydrogenated Poly(C6-14 Olefin), Beeswax, Caprylic/Capric Triglyceride, Polyglyceryl-2 Stearate, Dipropylene Glycol, Isododecane, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Stearyl Alcohol, Glycol Stearate SE, Sodium Polyacrylate, Hydroxyacetophenone, Stearic Acid, Dimethiconol, Dimethicone/Vinyl Dimethicone Crosspolymer, Hydrogenated Polydecene, Hydrogenated Lecithin, Tranexamic Acid (1,000ppm), Betaine, Glutathione (1,000ppm), Panthenol, Fragrance, Hippophae Rhamnoides Fruit Oil, Butylene Glycol, Adenosine, Sorbitan Isostearate, Caprylyl Glycol, Trideceth-6, 1,2-Hexanediol, Disodium EDTA, Sodium Hyaluronate, Ascorbic Acid
Within-host evolution of Pseudomonas aeruginosa reveals adaptation toward iron acquisition from hemoglobin
This means symptoms like: chronic pelvic pain painful ovulation painful bowel movements fatigue endo belly pulling or tugging pain worsening symptoms after surgery may all be driven by more than one mechanism