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Timing depends on individual dose, duration of use, and planned pregnancy onset, requiring coordinated provider guidance

this change in the protein sequence reduces enzyme activity and therefore could influence tissue susceptibility to oxidative stress [23]

Medications included other noninsulin, non-GLP-1RA glucose-lowering agents, antihypertensive drugs, statins, non-GLP-1RA anti-obesity medications (that is, orlistat, phenterminetopiramate, naltrexonebupropion, diethylpropion, phentermine and benzphetamine), corticosteroids, antipsychotics and antidepressants

Semaglutide belongs to the fast-growing class of GLP-1 therapies used for the treatment of type 2 diabetes and obesity

Health-state utilities for QALY calculations were sourced from published literature [2327]

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