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Alterations in xenobiotic metabolism in the long-lived Little mice

Cell culture HOXC8-imESCs, Control-imESCs, and parental cell line imESCs were maintained by 10 cm collagen-coated culture dishes (Corning Life Science, Tewksbury, MA) in DMEM/F12 medium (Wako, Osaka, Japan), supplemented with 10% FBS (Gibco, Rockville, MD), 2 mM L-glutamine (Gibco), and a 1% antibiotic-antimycotic solution (Wako), at 37 C in a humidified atmosphere of 5% CO and 95% air

8 Ex vivo studies further confirmed GAPs efficacy in reducing oxidative deoxyribonucleic acid (DNA) lesions and cyclobutene pyrimidine dimers under UVA and UVB irradiation, respectively, though these findings were limited by the small number of biomarkers evaluated

An antioxidant for the maintenance of good health