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Results showed that the probability of oral semaglutide being cost-effective was 0% at a WTP of $12,176.1 and $24,352.2 per QALY

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The difference between effective dosing and overdosing can be narrow at higher concentrations

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Another study found that GLP-1R activation in Brunners glands upregulated barrier defense genes, an effect entirely absent in GLP-1R knockout mice (53)