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(2022) investigated the role of matrine in the pathogenesis of CRC and found that matrine induced the upregulation of Erlin1 in CRC cells

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Researchers may not be able to conclude that excessive cell death induced by ferroptosis is associated with pathogenic processes based only on the preventive effect of ferrostatin-1 or liproxstatin-1 on cell death 21 , as these compounds are essentially antioxidants and may inhibit other ROS-dependent forms of cell death, such as necroptosis 46