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In highly glycolytic tumors, Treg cells take up lactate through monocarboxylate transporter 1

MAT is also called S-adenosylmethionine synthetase

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10 To test whether downregulation of Pdcd4 enhanced p70S6K1 phosphorylation by BMS-754807 to promote cell survival, we treated Pdcd4 knockdown (HT29-P) and LacZ shRNA transfected control (HT29-L) cells with BMS-754807 for 072 h