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44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model
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Figure 5 3.1 Genetic factors The gut microbiota significantly influences the development of atherosclerosis, with genetic factors playing an important role
(PubMed) Davini P, Bigalli A, Lamanna F, Boem A
It is important to note that the ASD-associated phenotypes identified in this study were determined in a population of individuals that are presumed to have idiopathic autism
