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The study followed patients taking tirzepatide at 5mg, 10mg, and 15mg doses, and patients taking semaglutide at 1mg over 40 weeks

Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype

In humans, GLP-1 alters palatable food intake and improves activity deficits in the insula, hypothalamus, and orbito-frontal cortex (OFC)

While the program starts with structured meal replacements, its ultimate goal is to help participants transition to healthy, self-prepared meals

The GLP-1 class has its own specific rules some shared across all medications in the class, some unique to semaglutide or tirzepatide specifically

Youre now one-third of the way through the typical titration schedule, and the cumulative effects are becoming substantial