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During clinical trials of oral tranexamic acid, a patient experienced a severe allergic reaction including dyspnea, tightening of throat, and facial flushing that required emergency medical treatment

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Since penetratin has the disadvantages that relatively high doses of penetratin are required for nasal insulin absorption (Khafagy et al., 2009a), several analogs of penetratin were designed looking to optimize the efficacy of transepithelial insulin delivery

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Evaluation of muscle biopsies can provide an accurate diagnosis in a large percentage of these cases, allow the muscle pathologist to make an accurate prognosis, and suggest specific therapies