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Hormone and Metabolic Research

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Both 25-hydroxylases (CYP2R1 and CYP27A1) were expressed in the liver, while CYP27A1 expression was seen only in cultured hepatocytes (FL83B mouse hepatocyte cell line)

Researchers classify it as a "stable gastric pentadecapeptide" because of its unusual stability in the harsh acidic environment of the stomach

However, our findings are consistent with previous studies of other BBSome genetic knockouts ( Bbs2 / and Bbs4 / ), which demonstrate that dysregulated leptin receptor signaling is a key ciliopathy-mediated disruption contributing to obesity in BBS

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