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Tissue-targeted delivery or isoform-biased agonists may improve therapeutic index where cardiometabolic benefit is desired with minimal off-target receptor engagement

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Cecchi L, DAmato G, Annesi-Maesano I

(2015) conducted a meta-analysis of 6 randomized controlled trials involving Cerebrolysin in Alzheimer's disease, finding statistically significant improvements in global clinical outcomes and cognitive measures at 24 weeks (PMID: 25832905) Cochrane Systematic Review: Cui et al

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