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The decrease in reaction rate is caused by the decrease in [SAM] and the increase in [SAH], which inhibits DNMT

Adverse reactions reported in pediatric patients were similar to those seen in adult patients, with the exception of clinically significant weight loss in two pediatric patients at doses of 60 mg per day and higher

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in: PubMed | Google Scholar 1 Department of Cellular and Molecular Medicine, Lerner Research Institute, 2 Center for Microbiome and Human Health, and 3 Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA

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In a clinical trial, one-year dulaglutide treatment in individuals with chronic kidney disease (CKD) and T2D resulted in an increased estimated glomerular filtration rate compared to insulin glargine