Following the KEAP1 inactivation, the expression and the nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) are increased, which subsequently promotes the transcription of antioxidant proteins like superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1), and leads to the mitigation of synovial inflammation
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Microglia are also known to secrete GLP-1(Kappe et al., 2012)
Helps support heart health and healthy cholesterol
10.1016/j.bbadis.2017.08.033 109 WagnerS.SeidlerT.PichtE.MaierL
Thyroid Disease Types and Tirzepatide Safety Considerations Patients with Hashimoto's thyroiditis (autoimmune hypothyroidism) generally tolerate tirzepatide well, provided TSH is controlled and monitored closely during weight loss