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Future GLP-1 research directions include combination therapies with other hormones, personalized dosing based on genetic profiles, extended-release formulations, oral delivery systems, and dual-receptor targeting approaches

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In a widely cited New England Journal of Medicine trial using once-weekly semaglutide 2.4 mg plus lifestyle intervention in adults with overweight or obesity without diabetes, participants had a substantial and sustained reduction in body weight over 68 weeks

Contraindicaciones absolutas No use medicamentos GLP-1 y dual GIP/GLP-1 si tiene alguno de los siguientes: Antecedentes personales o familiares de carcinoma medular de tiroides (MTC) o sndrome de neoplasia endocrina mltiple tipo 2 (MEN2) Antecedentes de pancreatitis o gastroparesia sintomtica Enfermedad gastrointestinal grave Embarazada o planeando un embarazo Reflexiones finales Los receptores GLP1 y dual GIP/GLP1 se utilizan ahora ampliamente para ayudar a controlar la diabetes tipo 2 y la obesidad