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Ayton S, Lei P, Duce JA, Wong BX, Sedjahtera A, Adlard PA, et al
Oxidative stress, generated by activated immune cells, produces reactive oxygen species (ROS) and nitric oxide, causing DNA damage in gametes and embryos, reducing sperm motility, and impairing fertilization ( 2.3 Oxidative stress and ferroptosis in endometriosis Ferroptosis, a novel iron-dependent programmed cell death characterized by the accumulation of lipid peroxides, is distinct from apoptosis, necrosis, and autophagy, and has been closely linked to female infertility, including endometriosis-associated infertility ( 2+ + H 2 O 2 Fe 3+ + OH + OH), producing highly toxic hydroxyl radicals that target lipids, proteins, and nucleic acids, thereby exacerbating oxidative stress
It may additionally influence bone metabolism through immune system modulationvia the secretion of microbial metabolites that interact with immune cells (e.g., T cells, B cells), activate the intestinal mucosal immune response, and induce the production of pro- or anti-inflammatory mediators and cytokines involved in the regulation of bone remodeling (210)
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