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This recurrence is attributed to the presence of residual tumor tissue and tumor stem cells which serve as the origin for future recurrences (105)

Additionally, the PI3K-Akt pathway is often synergistically activated, modulating cell survival, metabolism, and inflammatory signaling during the immune response 145

Cleland, W

C., Berge, C

Lussier-Cacan et al, 1996)

Early on, symptoms may be mild, but if the condition worsens, not only can the same symptoms become more severe, but you can also develop different ones