A small number of real human trials have found a topical glutathione lotion: The honest caveat is that the current evidence is still thin (few studies, small groups, short timelines)
Schizophr Res 2006
13 Nonetheless, localized use of skin bleaching agents may be of benefit to pigmentary disorders, thus its important to fully evaluate the safety and efficacy of topical glutathione in this context
In liver disease, S100A9 is released during liver necrosis, which binds to NLRP3 on hematopoietic stem cells and myofibroblasts, mediating an increase in the expression of TNF and IL-17 [197], which triggers an inflammatory response and promotes the synthesis of extracellular collagen, ultimately leading to liver fibrosis [198]
10.18632/aging.101808 206 WuY.LuJ.AntonyS.JuhaszA.LiuH.JiangG.et al (2013)
The model is also consistent with published results that show that female mice are less susceptible than males to hepatotoxicity due to acetaminophen overdose and suggests that this might also be true for humans, though the human epidemiological data are contradictory
