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This off-label use of the drug has gained attention, but it is important to understand the safety and efficacy of Topamax for weight loss

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The once-weekly triple-hormone receptor agonist was generally well tolerated and provided substantial reductions in weight, as well as clinically meaningful improvements in health outcomes for patients with obesity, OSA, and knee OA, said Ania Jastreboff, MD, PhD, Professor at Yale University School and Director of the Y-Weight Obesity Research Center

This is exacerbated by the fact that almost all advertisements for GLP-1s as a mode of weight loss show a mid-size person injecting the medication to lose weight