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The rationale for testing drug combinations in aging intervention studies

Apply a thin layer to clean, dry skin once or twice daily, or as instructed

In mammalian nervous systems, many different types of chemical substances, including amino acids (e.g., glutamate), monoamines (e.g., dopamine, norepinephrine), acetylcholine, peptides (e.g., substance P), serve as neurotransmitters to bind their corresponding receptors, then activate ion channels, and consequently produce ion flux 1 , thereby inducing membrane potential changes that lead to signal propagation for neurotransmission 1,2,3,4

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They proposed a non-genomic mechanism based in in vivo model study, in which ER forms a complex with IRS1, triggering PI3K/AKT pathway in the prepubertal stage