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Heres what WORKS based on decades of clinical evidence and real-world outcomes: Therapeutic testosterone replacement therapy (TRT) when indicated, dosed properly, and with appropriate monitoring and estrogen management

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Additionally, significant changes were noted in the composition of the bone matrix of these animals, with decreased enzymatic cross-linking of the collagenous matrix, which clearly worsened the compromised biomechanical strength and contributed to the observed bone fragility [44]

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