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During the weight maintenance phase, weight regain can occur secondary to decreased energy expenditure and increased energy efficiency, which together result in a net decrease in caloric needs 5,6,7,8

Rare Diseases - Glutathione Synthase Deficiency Glutathione synthase deficiency, or proglutamicaciduria, is the most severe form of glutathione deficiency

It is even more significant in Mounjaro (tirzepatide) which will likely be FDA approved by the end of the year for weight loss

Semaglutide GLP-1, acting as a glucagon-like peptide-1 (GLP-1) receptor agonist, exerts its effects by impacting appetite regulation in the brain, leading to reduced food consumption, and calorie intake, and ultimately facilitating weight reduction

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Still, a large-scale French study did find a potential link between GLP-1 use and thyroid cancer, especially in patients who used the drug for more than a year