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Neuroimaging data further indicated that carriers of the 168Ser allele displayed enhanced blood oxygen leveldependent activation in the globus pallidus during feedback-related reward processing, suggesting altered reinforcement sensitivity within basal ganglia circuits [73]
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Furthermore, investigations into the combination of CB-839 with immunotherapy have yielded encouraging outcomes, exemplified by its synergistic effect with nivolumab in patients diagnosed with melanoma, clear cell renal cell carcinoma, and NSCLC [217]
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Targeting IL-17 and TH17 cells in chronic inflammation
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