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Ask your healthcare provider before adding a laxative or other medication if constipation is persistent or you have other medical conditions

Kreis F, Wright AJ, Hesse F, Fala M, Hu DE, Brindle KM

Bottom line Oral semaglutide is a once-daily, needle-free option available for both weight loss (Wegovy pill) and type 2 diabetes (Rybelsus)

Without these, the benefits are often reduced or temporary

Be prepared with comorbidity documentation anyway because it strengthens your prior authorization

Additional tirzepatide safety concerns include risk of acute gallbladder disease (presenting as right upper quadrant pain, fever, or jaundice), acute kidney injury from dehydration (especially if severe gastrointestinal symptoms occur), and hypersensitivity reactions