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Under hypoxic conditions, the inhibition of PHDs activity results in HIF- accumulation and translocation to the nucleus, which, together with the HIF- subunit forms, can activate transcription factors (HIF-1, HIF2, or HIF-3) [141]

Niacinamide blocks the transfer of pigment from melanocytes to the surrounding cells

Norouzi S, Majeed M, Pirro M, Generali D, Sahebkar A

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Anti-infective agents 13 (1), 316