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S McKinley-Barnard, T Andre, M Morita, DS Willoughby

Ongoing trials are comparing outcomes

Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload

TRIUMPH-1 (NCT05929066), the Phase 3 registration trial for the obesity indication, reported topline results on May 21, 2026 : average weight loss of 28.3% at 80 weeks at the highest dose in 2,339 participants, versus 2.2% on placebo, and 30.3% at 104 weeks among participants with a BMI of 35 or above who continued in a pre-specified extension

The DoD uses a Technology Readiness Level (TRL) scale from 1 to 9 to assess how mature a technology is, and the funding mechanisms available to a company shift significantly as that maturity increases

Discontinue use and consult a clinician if unexplained symptoms arise