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According to Rukhlenko et al

Overt vitamin B6 deficiency is rare, but approximately 10 percent of Americans may have inadequate B6 status, and it often occurs with deficiencies in other B vitamins like folate and B12

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Preclinical and early human data suggest it may promote lipolysis, inhibit lipogenesis, and preferentially act on adipose tissue by influencing beta3 adrenergicmediated pathways and hormonesensitive lipase activity

B12 overdoses are unusual

Choosing between B12 shots and supplements can be overwhelming, but prioritizing your health is key