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DOI: 10.1016/j.phrs.2022.106257 [Google Scholar] Liu QK
Targeting ferroptosis effectively reduces the extent of renal interstitial fibrosis, improves renal function, and delays the progression from AKI to CKD
Activated IGF-1R phosphorylates insulin receptor substrate proteins (IRS-1 and IRS-2), which recruit and activate PI3K
Comment: A commenter stated that replacing the health equity adjustment with a population adjustment does not offer the same level of focus or transparency on fairness in care delivery and that the new language risks weakening CMS' longstanding commitment to addressing inequities
It features an arginine substitution at position 3 and an extra 13 amino acids at the N-terminus, making it about three times more potent than native IGF-1 with a half-life of 20-30 hours
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