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Another notable challenge is the cellular dependence on cysteine, as demonstrated by mesenchymal TNBC cells, whereas non-mesenchymal TNBC cells frequently display resistance to cysteine deprivation (27)

ROS processing and regulation of ROS signalling Accumulating evidence suggests that ROS are essential metabolite markers, or signals of living cells (Van Breusegem et al

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(5) PRODH: Proline dehydrogenase (PRODH) is a mitochondrial flavoenzyme that catalyzes the first step of proline catabolism, converting proline into 1 -pyrroline-5-carboxylate (P5C) while transferring electrons to ubiquinone (CoQ 10 ) in the mitochondrial ETC

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