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AGING AT THE CELLULAR LEVEL In 2013, Lpez-Otn et al [14] defined nine cellular and molecular hallmarks of aging, laying a crucial foundation for future research in the field

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However, in atretic follicles, FSH may activate autophagy via different signaling pathways, leading to granulosa cells degradation and triggering follicular atresia ( Overall, the role of autophagy in establishing the follicular pool and promoting follicular survival highlights its potential as a novel therapeutic target for addressing DOR in vulnerable populations, such as those exposed to chemotherapy, environmental toxins, or genetic disorders (Figure 3B)

(PubMed) Steiner M, Khan AH, Holbert D, Lin RI

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