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doi: 10.1007/s00223-021-00911-7

The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment

Theyre like super-sized treatment options," says Dr

When the body is aging, the energy supply of the cells is insufficient

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But the core mechanism remained primarily intake reduction