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Small skin studies reported modest pigmentation changes but do not establish predictable or permanent skin lightening

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Nasopharyngitis and headache were the most common adverse events, but the adverse event rates were similar in the treatment and placebo groups

Tirzepatide is a once-weekly injectable, dual glucagon-like peptide 1 (GLP-1) receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist