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Mental stress impacts the nervous system and elevates cortisol levels which promotes energy storage and invites food cravings for ultra-processed comfort foods

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Kovacic P: Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer

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Clinical studies provide direct evidence: GLP-1 analogue therapy significantly reduced sCD163 (a marker of inflammatory macrophage activation), independent of changes in body weight, fructosamine, and HbA1c

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It was hypothesized that a moderate increase in testosterone concentration would affect microvasculature and mitochondrial protein levels and would cause mitochondrial oxidative capacity of skeletal muscles to increase, but we did not expect it to affect oxygen consumption per lean muscle mass due to the simultaneous increase of lean muscle mass and Hb mass

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