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[45] Consoli A, Formoso G

In hepatocytes, hexokinase activity is dependent on the insulin/glucagon ratio for the removal of excess glucose from the blood and its targeting to the glycolytic or glycogenesis pathway, through stimulation of glucose-induced glycogen synthesis 20,21

What the Studies Actually Showed: Preclinical Data Study 1: Fat and Liver Mass Drop Far Faster Than Muscle In diet-induced obese mice treated with tirzepatide (the dual GLP-1/GIP agonist in Mounjaro and Zepbound) for 14 days, researchers found a 73% reduction in body fat and only a 13% reduction in LBM