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Some people experience severe nausea, vomiting, or other side effects that make GLP-1 injections intolerable even at low doses

Mechanistically, BMP4 overexpression upregulates the expression of brown fat marker genes such as UCP1 and PGC-1, while significantly reducing the levels of pro-inflammatory cytokines including IL-1, IL-6, monocyte chemoattractant protein 1 (MCP-1), and TNF

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Nevertheless, This study provides the first evidence of a formulation-and dose-dependent ION risk, with the strongest association observed for Wegovy, write the researchers, concluding: These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy. The authors of a linked commentary agree

Gastroenterology 169 , S-46 (2025)

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