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Rapid weight reduction can signal energy deficit to the hypothalamus, potentially suppressing gonadotropin-releasing hormone (GnRH) pulsatility

DOI: 10.3390/ijms20143435 [Google Scholar] Sato T, Shimizu T, Fujita H, Imai Y, Drucker DJ, Seino Y, et al

Preclinical and observational data suggested possible benefits, spurring rigorous clinical testing

As a result, these agents may influence sympathetic and parasympathetic tone

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