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Gq activates phospholipase C (PLC), leading to hydrolysis of phosphoinositol diphosphate (PIP2) into products like IP3 and DAG, resulting in elevated Ca levels

however, analgesic and anti-inflammatory doses can yield plasma concentrations ranging from 30 to 150 M (Dovizio et al, 2013)

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The solution is a cocktail of vitamins, antioxidants and exfoliating AHAs and BHAs

Researchers have speculated that this dual mechanism could produce signaling environments that resemble naturally occurring endocrine pulsatility more closely than isolated stimulation models