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Researchers working in sports science or applied physiology must account for this classification when designing any protocols involving human subjects

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Other side effects, like thyroid problems, gallstones, or pancreatitis, and even a rare form of blindness, are far less common, but often necessitate discontinuation

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Topical applications may show initial improvements in skin texture and hydration within 2-4 weeks, with more significant changes in collagen production and skin firmness becoming apparent after 8-12 weeks of consistent use