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UK guidance typically recommends: Loading doses of colecalciferol (e.g., total of approximately 300,000 IU over 6-10 weeks) for confirmed deficiency Maintenance therapy with 8002,000 IU daily thereafter Higher doses may be required for malabsorption conditions Before starting high-dose vitamin D, check corrected calcium and renal function

Allergic reactions are rare

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For example, a healthy person taking a 500 mcg oral B12 supplement will only absorb about 10 mcg

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