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The circumventricular organs actually express high levels of GLP1 receptors (Cork et al., 2015

[15] [37] [38] In August 2025, the Food and Drug Administration (FDA) expanded the indication for semaglutide (as Wegovy) to include the treatment of noncirrhotic metabolic-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) in adults

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Thats a clinical way of saying that these medications seem to be supporting proper immune function