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An open question with no conclusive answers seemingly not on the horizon

Substantial evidence shows that some miRNAs (such as miR-1, miR-206, and miR-148a-3p) can suppress the proliferation, survival, invasion, and metastasis of ovarian cancer cells by directly targeting c-Met, and subsequently regulating downstream signaling pathway to serve as tumor suppressors such as PI3K/Akt/mTOR and ERK1/2 pathways (Qu et al., 2017

Nature Materials , 20 (9), 12901299

Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]

Various monoclonal antibodies have been developed to block c-Met/HGF signaling pathways, some of which competitively bind to c-Met, and the others are served as traps for c-Met, preventing ligand attachment and dimerization of c-Met [168]