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The pulsatile release appears important for optimal metabolic effects and reduced side effects

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FDA therefore identified a theoretical carcinogenic concern where chronic exposure activates telomerase or extends telomeres in cells capable of malignant transformation

While bronchoscopy is not routinely recommended [87, 88], flexible bronchoscopes are increasingly used on ICU for airway clearance and sampling of respiratory secretions, where less invasive methods are insufficient [88]

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