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When preventable harm occurs, questions may arise about whether appropriate warnings were provided and whether manufacturers or other responsible parties can be held accountable

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First, as TriNetX is a registry-based database, the risk of misidentification and underrepresentation exists, particularly among individuals with milder disease or limited healthcare utilization, which may affect the generalizability of our findings

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doi: 10.3389/fcimb.2021.676276 31 RussellB

IRB/UNCOMIRB20221149, dated 4/9/2022, following evaluation of the protocol, data collection methods, and consent documentation