Comparison of the protective efficacy between intratympanic dexamethasone and resveratrol treatments against cisplatin-induced ototoxicity: an experimental study
One hypothesis is that we observed a greater induction of NRF2 through liver-specific Gclc deletion as compared to KEAP1 inhibition with CDDO-me because CDDO-me is a weaker inhibitor of NRF2-KEAP1 interaction compared to the ROS generated following GSH depletion
Nonetheless, we have shown that with appropriate choice of a relatively inert third-row transition metal ion osmium(II), a -bound arene, a substituted chelated diamine ligand which stabilises the active 16-electron coordinatively unsaturated catalyst, and chiral centres on the diamine backbone and the metal, then in-cell enantioselective transfer hydrogenation catalysis can be achieved, using a non-toxic concentration of sodium formate (a naturally occurring metabolite in human plasma) as a source of hydride [16]
von Martels JZH, Bourgonje AR, Harmsen HJM, Faber KN, Dijkstra G
The plaintiffs were given time to file any opposition to Walmarts requests
IV glutathione delivers the highest absorption but needs a clinical setting
