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1 Introduction Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia (elevated blood glucose), which is caused by a lack of insulin or failure of insulin, resulting in cells being unable to absorb glucose, thus increasing blood glucose levels

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Methods: We used an antisense oligonucleotide (ASO 56) to target the TEAD1 pre-mRNA upstream of exon 5, blocking hnRNPU binding and reducing TEAD1 DeltaEx5 expression (See scheme)