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doi: 10.1016/j.regpep.2004.12.015 21 GironacciMMVicarioACerezoGSilvaMG

Selection is based on diagnostic findings, symptom patterns, and prior response to treatment

Methods Cell viability assays were used to determine the effect of low concentrations of tamoxifen on the proliferation of multidrug resistant cells (CHO R C5 and MDA-Doxo 400 ), expressing P-gp, their parental cell lines (AuxB1 and MDA-MB-231) or P-gp-CRISPR knockout clones of AuxB1 and CHO R C5 cells

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So once fat cells are removed from a localised area your results are as good as permanent

It establishes a clear baseline and is the easiest to replicate