Decreased GSIS in hyperuricemia may be due to decreases in MafA protein expression [39] as MafA is a key regulator of insulin secretion in -cells [41]
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Part of that effect happens in the brain
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The lowest % of atretic follicles and degenerated corpora lutea was detected in the DOX+(SP + L-car) group, followed by the DOX + L-car group and then the DOX + SP group, as the histoarchitecture of the DOX+(SP + L-car) group was more or less the same as the control group
Biomolecules 11 (10), 1478