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Excessive NO competes with the antioxidants, MnSOD and GSH, for superoxide and promotes the genera- tion of peroxynitrite
Gut barrier dysfunction and endotoxemia Intestine is one of the most crucial internal barriers and its disturbance leads to an immune response as bacterial products pass through the gut, and evidence shows that the immune systems of patients with MASLD are primed toward a pro-inflammatory state
In addition, multiple fungal species are also found in various cancers, affecting the immune response, with possible clinical implications on disease progression and response to various treatments 3
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(Like the ones that cause frown lines or pull your nasal tip down when you smile)
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