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Contraindications XIGDUO XR is contraindicated in patients with: Severe renal impairment (eGFR below 30 mL/min/1.73 m2) or end-stage renal disease [see Warnings and Precautions (5.1)]

To keep portions manageable: Use more tuna than beans Skip heavy dressings Eat it plain or over a small bed of greens This format is easy to portion and easy to pause if fullness hits early

Medications containing semaglutide and tirzepatide are commonly linked to stomach-related side effects because they strongly affect appetite and digestion

Pricing Disclaimer: Prices mentioned were observed on company websites and press releases as of December 26, 2025

Research has found that after 56 weeks, roughly 50% of people taking Contrave lost more than 5% of their body weight

These results were published in February 2025 (Hendershot, Bremmer, Paladino)